Related article: ADH antagonists- site of action? collecting ducts adverse effect of Nitroprusside? cyanide toxicity (releases CN) adverse effects of beta-blockers? impotence, asthma, CV effects (bradycardia, CHF, AV block), CNS effects (sedation, sleep alterations) adverse effects of Captopril? fetal renal toxicity, hyperkalemia, Cough, Angioedema, Proteinuria, Taste changes, hypOtension, Pregnancy problems, Rash, Increased renin, Lower Angiotensin II Buy Serpina (CAPTOPRIL) adverse effects of Clonidine? dry mouth, sedation, severe rebound hypertension adverse effects of ganglionic blockers? severe orthostatic hypotension, blurred vision, constipation, sexual dysfunction adverse effects of Guanethidine? orthostatic and exercise hypotension, sexual dysfunction, diarrhea adverse effects of Hydralazine? nausea, headache, lupus-like syndrome, reflex tachycardia, angina, salt retention adverse effects of Hydrochlorothiazide? hypokalemia, slight hyperlipidemia, hyperuricemia, lassitude, hypercalcemia, hyperglycemia adverse effects of Loop Diuretics? K+ wasting, metabolic alkalosis, hypotension, ototoxicity adverse
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effects of Losartan? fetal renal toxicity, hyperkalemia adverse effects of Methyldopa? sedation, positive Coombs'
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effects of Minoxidil? hypertrichosis, pericardial effusion, reflex tachycardia, angina, salt retention adverse effects of Nifedipine, verapamil? dizziness, flushing, constipation (verapamil), nausea adverse effects of Prazosin? first dose orthostatic hypotension, dizziness, headache adverse effects of Reserpine? sedation, depression, nasal stuffiness, diarrhea Amiodarone- toxicity? pulmonary fibrosis, corneal deposits, hepatotoxicity, skin deposits resulting in photodermatitis, neurologic effects, consitpation, CV (bradycardia, heart block, CHF), and hypo- or hyperthyroidism. antidote? slowly normalize
K+, lidocaine, cardiac pacer, and anti-Dig Fab fragments Beta Blockers- CNS toxicity? sedation, sleep alterations Beta Blockers- CV toxicity? bradycardia, AV block, CHF Beta Blockers- site of action? Beta adrenergic receptors and Ca2+ channels (stimulatory) BP? decrease BP? decrease Bretyllium- toxicity? new arrhythmias, hypotension Ca2+ channel blockers- clinical use? hypertension, angina, arrhythmias Ca2+ channel blockers- mechanism? block voltage dependent L-type Ca2+ channels of cardiac and smooth muscle- decreasing contractility Ca2+ channel blockers- site of action? Cell membrane Ca2+ channels of cardiac sarcomere Ca2+ channel blockers- toxicity? cardiac depression, peripheral edema, flushing, dizziness, constipation Ca2+ sensitizers'- site of action? troponin-tropomyosin system Cautions when using Amiodarone? check PFTs, LFTs, and TFTs class IA effects? increased AP duration, increased Order Serpina Online ERP increased QT interval. Atrial and ventricular. class IB- clinical uses? post MI and digitalis induced arrhythmias class IB- effects? decrease AP duration, affects ischemic or depolarized Purkinje and ventricular system class IB- toxicity? local anesthetic. CNS stimulation or depression. CV depression. class IC- effects? NO AP duration effect. useful in V-tach that progresses to V-fib and in intractable SVT LAST RESORT class Buy Cheap Serpina IC- toxicity? proarrhythmic class II- effects? decrease the slope of phase 4, increase PR interval (the AV node is particularly sensitive) class II- mechanism?